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Scoring of side-effects: key points
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Use a published system
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Minimize the number of variables
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Use forms easy to read
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Define endpoints
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Test inter-observer variability
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Document observations (e.g. pictures)
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Record
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Baseline morbidity
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Invasive procedures
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Comorbidity
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Other relevant treatments
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Take home messages
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Normal tissue side effects are mandatory to score
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Therapeutic ratio
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Quality assurance (QA)
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Both early and late reactions may develop in the same
organ
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Use validated scoring systems to record normal tissue
effects
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Score before, during and after RT!
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Extend follow-up to several years after RT to get knowledge
on late morbidity
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