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2 Distinct G2 checkpoints induced by IR
Late
– Dose dependent
– Applies to cells irradiated in G1 or S-phase
–
“
classical
”
G2 delay
– ATR dependent
– May affect radiosensitivity
Early
– Dose independent (1-10Gy)
– Applies to cells irradiated in G2
– ATM dependent
– Does not affect radiosensitivity
SLOW