00_MJ_Intro_Budapest16.pptx

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Summary of Checkpoints
• Checkpoints are activated by inhibiting CDK’s
• Checkpoints are often disrupted in cancer
• 4 Checkpoints are activated by IR
– G1 (ATM-p53), S (ATM), G2 early (ATM/ATR), G2 late
(ATR)
• Loss of checkpoints affects tumor proliferation after
IR
– Can affect cell cycle Redistribution, response to
multiple fractions