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Back to the future: SBRT & tumor
hypoxia
• With the developments in image-guided
radiotherapy (IGRT), the use of high single doses
or a few large fractions is rapidly gaining popularity
in the clinic.
• Stereotactic Body RadioTherapy (SBRT) is now
widely used for early stage lung cancer, but also
metastases in various sites.
• One reason fractionated radiotherapy became
standard was the absence of a therapeutic window
with large single doses, predominantly because of
hypoxia!