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Key points
• Hypoxic cell radioresistance is a significant cause of
faillure in local tumor control in particular in SCC of head
and neck and uterine cervix.
• Using high oxygen content gas breathing, chemical
radiosensitizers or blood transfusion have shown mixed
results.
• Meta-analysis of randomized trials does however
demonstrate a significant benefit and level 1a evidence for
head and neck tumors