00_MJ_Intro_Budapest16.pptx

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Making choices: Therapeutic index

Bcr-abl (Gleevec)

B-raf (PLX4032)

EGFR (Iressa)

PARP/BRCA2

VEGF (Avastin)

Hypoxia tolerance

Oncogene addiction

Synthetic lethality

Contextual synthetic

lethality