00_MJ_Intro_Budapest16.pptx

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Proliferation

• MAPK signaling

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Radiosensitivity

• PI3K signaling

• DNA repair

•Cetuximab (C225)

Irradiation

REPOPULATION

INTRINSIC

RADIOSENSITIVITY

EGFR

Example 1: Target driven lethality (EGFR)