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Vascular disrupting agents
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Working mechanisms
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Selective shut-down of established tumor blood supply
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Selectivity for tumor over normal vessels
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Interrupt blood flow to tumor
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Induction of hemorrhage
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Necrosis (due to oxygen and nutrient starvation)
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Examples
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Flavone acetic acid family, combrestatins, arsenic
trioxide, colchicine derivates,...
47
Tozer GM Nat Rev Cancer 2005
Vascular disrupting agents
48
Tozer GM Nat Rev Cancer 2005