00_MJ_Intro_Budapest16.pptx

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ESTRO

70 70 70 70

70 70 70 70

70 70 70 70

70 70 70 70

CTV 70 Gy

PTV 70 Gy

Standard arm

Median GTV dose:

70 Gy

75 80 70 86

86 70 80 70

70 75 70 75

80 70 86 80

CTV 70 Gy

PTV 70 Gy

Experimental arm A:

PET-based dose increase

Median GTV dose: 75 Gy

high

low

PET signal

intensity

Dose-painting: randomized phase-

II study design