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Syngeneic mouse models
• Tumor models derived from spontaneous tumors in mice
• Usually non-immunogenic
• Can be transplanted to other syngeneic mice
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Xenografts
• Human tumors grown in
immunodeficient mice:
Nu/Nu (nude mice), SCID
Orthotopic models
Subcutaneously
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patient-derived cell lines
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patient-derived organoids
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patient-derived xenografts
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Tumors arising in genetically modified mice
• Transgene, knockout, knock-in, etc.
Tumor Models