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Regrowth Delay Assay
•
Comparison of growth curves of
treated and untreated tumors gives
the delay caused by treatment.
•
Relationshipbetween growth delay
and surviving fraction of stem cells
is complex.
•
Regrowing cells have different
environment: surrounded by dead
and dying cells; vascular network is
already in place.
•
Tumor bed effect
Growth Kinetics of Tumors, G.G. Steel, 1977