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Summary
• Response of tumors depends on
•
intrinsic cellular radiosensitivity
•
stromal interactions (vasculature)
•
microenvironment (hypoxia)
•
tumour volume (stem cell number)
•
cellular proliferation (repopulation).
• Tumor models can be used to explore
• different treatment regimes
• importance of biological pathways
• Volume response:
• measure time to regrowth, not regression.
• correct for doubling time when comparing tumors
• Tumor cure: gold standard
• not possible with drugs alone (insufficient kill)
• many animals and long time, so only use as confirmation