1393 / 1816
Conundrum of PST: current evidence
Krug D, et al. JCO 2015;33:A1008
GBG Trials: GeparTrio, GeparQuatro, GeparQuinto
Overall results:
•
5yr LRFS, 90% vs 81.5%, p=0.001 for
±
radiation
•
5yr DFS, 75% vs 67%, p=0.001 for
±
radiation
After pCR:
•
5yr LRFS, 96% vs 87%, p=0.051 for
±
radiation
No pCR:
•
5yr LRFS, 89% vs 81%, p=0.001 for
±
radiation
In multivariate analysis, adjusting for baseline
characteristics and pCR, RT was confirmed as an
independent prognostic factor for LRFS and DFS