1388 / 1816
Conundrum of PST: current evidence
Buchholz TA, et al. JCO 2001;20:17-23.
MDACC series:
predictive factors for LRR
Pre-PST factors:
✓
Increasing clinical T stage (p<0.0001)
✓
Nodal status (p<0.0001)
Post-PST factors:
✓
Size of residual primary tumour (p=0.0048)
✓
Increasing number of involved nodes (p<0.0001)
✓
No tamoxifen (p<0.0013)
LRR after pCR (n = 18) = 19%:
Achievement of pCR does not preclude the need for
PMRT if indicated by the initial stage of the disease