1385 / 1816
Conundrum of PST: current evidence
Mamounas E, et al. JCO 2012;30:3960-6.
Combined analysis of NSABP B18 and B27
Limitations:
•
Patients with T4 and N2 disease were not eligible
•
>85% patients diagnosed by FNA
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Unknown ER, PR, HER2 receptor status
•
Non-contemporary systemic treatment:
•
Tamoxifen given on the basis of age (>50years) not ER
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Chemotherapy schedules (AC*4 and AC*4-D*4)
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No trastuzumab
Predictors of LRR after primary chemotherapy