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Short and long term side effects aromatase
inhibitor
Most commonly reported symptoms
Menopausal symptoms
• Musculoskeletal symptoms (AIMSS)
•
Arthralgias
incidence is 40%, 15-20% reason for treatment discontinuation
•
Myalgias, tendonitis, and carpal tunnel syndrome
• Vaginal dryness and decreased libido
• Hot flushes
Osteoporosis
BMD -6 à 7% after 5 year compared to tamoxifen (+1 à 2%)
19-9-2017