1731 / 1816
TAM 5 years vs TAM 10 years
Thrombo-embolic disease RR: 1.87 ( p:0.01)
Endometrial cancer RR: 1.74 ( p: 0.0002)
Incidence of endometrial cancer 3.1% in the tamoxifen arm vs. 1.6%
(placebo).
Endometrial cancer–related mortality was 0.4% in the tamoxifen arm
vs. 0.2% in the placebo arm.
When compared to no TAM, the RR of 10 year TAM is between 4 and 5
Davies et al, Lancet 2013