1732 / 1816
Tamoxifen vs aromatase inhibitors
Differences
OR (AI vs TAM)
Absolute risk
( ) difference
NNH
Cardio vasc
disease
Hyper cholesterol
1.26 (1.10-1.43)
2.36 (2.15-2.60)
4,2 vs 3,4%
(0.8%)
132
Thrombosis
0.55(0.46-0.64)
1,6 vs 2,8% (1.2%) 79
Bone fractures
1.47(1.34-1.61)
7,5 vs 5,2% (2.3%) 46
Endometrial cancer 0.34(0.22-0.53)
0,1 vs 0,5% (0.4%) 258
NNH: number needed to harm
Amir et al, JNCI 2011