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Cosmetic results after breast conserving therapy
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Which factors play a role ? Several RCTs to investigate impact of:
Factor studied
Impact on cosmesis
Conclusion
Hypofx
No change in breast
appearance
No boost vs low boost
No boost better than boost
Prone vs Supine
Tendency for better outcome
prone than supine
2D CRT vs IMRT
Only benefit if scored by
physician at 5 yr, and if
patients are selected
Partial breast vs WBRT
Results conflicting
Hypofx:
Whelan 2008; Haviland 2013;
Prone vs supine:
Veldeman 2016;
2D CRT vs IMRT:
Pignol 2016; Mukesh 2014;
No vs low boost:
Vrieling 1999 & 2000, Hau 2013;
Low vs high
boost
: Brouwers in preparation;
PBI vs WBRT:
Polgar 2017, Coles 2017, Peterson 2015