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Effect of Tamoxifen in DCIS ?

NSABP-24 trial, 2011: N =1799 Tam vs placebo (all RT)

UK/ANZ trial, 2011: N = 1576 Tam vs placebo (half +/- RT)

Preventive effect on

Ipsilateral DCIS

NSABP

UK/ANZ

NSABP

UK/ANZ

Preventive effect on

contralateral DCIS

Staley et al, The Breast 2014