Effect of Tamoxifen in DCIS ?
NSABP-24 trial, 2011: N =1799 Tam vs placebo (all RT)
UK/ANZ trial, 2011: N = 1576 Tam vs placebo (half +/- RT)
Preventive effect on
Ipsilateral DCIS
NSABP
UK/ANZ
NSABP
UK/ANZ
Preventive effect on
contralateral DCIS
Staley et al, The Breast 2014