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Effect of Tamoxifen in DCIS?
NSABP-24 trial, 2011: N =1799 Tam vs placebo (all RT)
UK/ANZ trial, 2011: N = 1576 Tam vs placebo (half +/- RT)
NSABP
UK/ANZ
NO
significant effect on
ipsilateral invasive ca
NSABP
UK/ANZ
Preventive effect on
Contralateral invasive ca
Staley et al, The Breast 2014
Tamoxifen works mainly preventive in patients with
DCIS, but not therapeutic