570-571 / 1816
Impact of chemotherapy on local recurrence
•
NSABP B13, methotrexate
plus 5FU versus no
chemotherapy, LRR
dropped from 13% to 2.6%.
•
Housami meta-analysis was not able to
look at positive margins corrected for
chemotherapy or trastuzumab. Most
studies with adequate follow up
predated use of trastuzumab.
•
Most chemotherapy RCTs specify
adequate surgery with clear margins