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Can Boost remove the need for clear margins?
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Lupe et al, 2011. 2264 women treated with BCS
and WBRT and boost. 1980 had clear margins,
222 close and 62 positive margins. 5.2 year
follow up. 92% of close or positive cases had
boost.
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When close/positive margin cases were matched
to negative margin controls for other risk factors
such as age, grade, subtype, the difference in 5-
year LR remained significant (4.25% vs. 0.7%, p <
0.001).
•
Housami meta-analysis found that correction for
boost rates did not reduce the impact of a
positive versus a negative margin
0
1
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3
4
5
6
LR rate
P<0.001
negative close positve