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Summary 1

Consistent evidence that

positive margins result in higher

LRR, regardless of

Tumour biotype

Age

Systemic Treatment

Boost

Uncertainty regarding whether

residual disease is present or not

or whether it is small volume

(and likely to respond to RT/CT)

or large volume.

Data shows that local recurrence

at 5 years translates into

increased mortality rates at 15

years (EBCTCG)