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Large Danish Cohort (Bodilsen et al, 2016)

11 900 women treated with BCS

Median FU 4.9 years

Hazard ratio for a positive margin

2.51 but final positive margins very

rare (<1% of population.

Chemotherapy reduced risk by about

half but small numbers preclude

assessment according to margin

status

0

1

2

3

4

5

6

7

8

9

10

IBTR

Margin status and IBTR

positive close negative