210-211 / 2437
Gross Total Resection impacts
natural history of low-grade gliomas
•
Malignant transformation ranges between 4 and 29 months
•
45% of WHO grade II undergo anaplastic tranformation in 5
years
•
If resection > 90%
Median time to progression: 5.5 years
Median time to malignant transformation: 10.1 years
5yy survival rates is 97% (vs 76% if extent of resection <90%)
Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, Tihan T, Vandenberg S, McDermott
MW, Berger MS (2008) Role of extent of resection in the long-term outcome of low- grade hemispheric
gliomas. J Clin Oncol 26:1338–1345