70-71 / 2437
METABOLIC IMAGING
IMAGING TUMOR PROLIFERATION
[(18)F]-FLT-PET
fluorothymidine
• Uptake of FLT correlates with
Thymidine kinase-1 activity
expressed during DNA synthesis
• High correlation with Ki-67
expression (Yamamoto J Nucl Med
2012)
• Might be superior to MET for tumour
grading
• The kinetics of FLT uptake are
closely related to prognosis, early
efficacy of treatment and to outcome
(Wardak Clin Cancer Research
2011)
•
PITFALLS
:
• less sensitivity than MET for low
grade gliomas
•
CANNOT PREDICT GRADE
Oligodendroglioma Grade II
Astrocytoma Grade II
Anaplastic
Oligodendroglioma Grade III
GBM Grade IV