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PHYSIOLOGICAL IMAGING
MRI SPECTROSCOPY
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NAA
: marker of neural integrity
•
Choline
: membrane turnover
• Creatine: energetic
•
Myoinositol
: astrocytic marker
•
Lipid
: tissue destruction/necrosis marker
• Lactate: hypoxia marker
• Glutamine and Glutamate: excitatory markers
High choline correlates with high tumor proliferative index
Lower grades are associated with elevated MI/Cr ratio
Pitfalls
: - min 1 cm3 voxel size
- not suitable for posterior fossa lesions and lesions near bone
- common aspecific spectral findings
Provides insight into the biochemical profile