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LEAST COST FORMULATIONS, LTD.

824 Timberlake Drive, Virginia Beach, VA 23464-3239

Tel: (757) 467-0954 Fax: (757) 467-2947

E-mail:

office@lcftld.com

URL:

http://lcfltd.com/

TECHNICAL REPORT

NUMBER:

TR322

DATE: 2012 July 8

TITLE:

Statistical analysis of interlaboratory studies. XXXV. Reproducibility estimates

from proficiency test data.

AUTHOR:

R. A. LaBudde

ABSTRACT: The issue of estimating reproducibility effects from proficiency test (‘PT’) data is

discussed. It is recommended that such data may be used to estimate

reproducibility when: 1) There are sufficient collaborators (8 or more remain in

the final set of data); 2) Collaborator results are removed only for known cause

based on subject-matter expertise and facts. It is recommended that the method

used to estimate reproducibility effects is by the standard deviation of mean

(across replicates, if any) results for the entire dataset net of crude errors with

known causes, corrected for replication. If useful, a lower bound on

reproducibility may be obtained conveniently via the interquartile range of the

original dataset.

KEYWORDS:

1) PT

2) REPRODUCIBILITY 3) VARIANCE

4) ROBUST 5) OUTLIER

6) IQR

REL.DOC.:

REVISED:

Copyright 2012 by Least Cost Formulations, Ltd.

All Rights Reserved

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