1228-1229 / 1676
FMB
Cardiac risk
factors at time
of breast cancer
diagnosis
Years since breast cancer diagnosis
2p for
difference
between 0-9
and
10+years
0-9
10+
All years
RR*
RR
RR
None
1.0†
1.0†
1.0†
At least one
factor
3.22 (2.36, 4.39)
1.67 (1.28,2.18)
2.22 (1.82, 2.71)
0.002
*
Rate ratio (95% CI). Rate ratios estimated by logistic regression after stratification for country, and for age at
breast cancer diagnosis, year of breast cancer diagnosis, and years from breast cancer diagnosis to first
subsequent MCE (cases) or index date (controls)
† Baseline category
NEJM 2013; 368:987-98
Association between cardiac risk factors and subsequent rate of
major coronary events by years since breast cancer diagnosis