372-373 / 1676
Problems with RCT’s
Reduction of radiation-induced side effects
•
Technology development progress
versus
duration of RCT’s:
–
Outdated technology
•
Long latency times late side effects
•
Ethics and lack of equipoise (large
△
Dose)
•
Costs:
–
No reimbursement experimental arm
–
Costs for well powered RCT: 5-10 M€
•
Standard radiation technology does not exist