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•
Evidence based medicine
not synonymise
with RCT
•
Two examples:
–
The accuracy and precision of diagnostic tests
–
The power of prognostic markers and
prediction models
Sackett
et al
, BMJ 1996
Evidence-based medicine
David Lawrence Sackett
Can we use multivariable NTCP-models for
evidence-based
selection of patients
for and
clinical validation
of new radiation technologies
aiming at reduction of side effects?