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R-CHOP + X

RA-CHOP: stopped due to Avastin tox

R2-CHOP: lenalidomide (phase II, not better)

R-CHOP + bortezomib

R-CHOP + enzastaurin

R-CHOP + ibrutinib

R-CHOP + idelalisib

R-CHOP + ABT-199