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The faces of MZL

Extra nodal MZL

Splenic MZL

Nodal MZL

% on MZL

70%

20%

10%

Median age

60

65

50-60

Pathogenesis

Hp, C.jejuni, C.

psittaci, B

burgdoferi

Unknown, HCV

Unknown, HCV

t(11;18)

3q and gain 12q

Nil typical

Typical clinical

presentation

I

E

disease

Abnormal blood

count,

splenomegaly

Adenopathy

Third most common NHL (5-17% of total)