1333 / 1498
Splenic Marginal Zone Lymphoma
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Prominent splenomegaly: variable involvement of lymph nodes, bone
marrow, peripheral blood, Splenic hilar lymph nodes and bone marrow are
often involved
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lymphoma cells may be found in the peripheral blood as villous
lymphocytes <1%
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Association with hepatitis C infection has been reported, although the
prevalence ranges from 36% to less than 10%
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Abdominal discomfort due to splenomegaly
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Modest cytopenias that are primarily due to splenic sequestration (less
marrow infiltration).
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Typically diagnose on BM, may need splenectomy
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Intergruppo Italian Linformi 309 patients, 5-year cause-specific survival
76%.