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6

x CHOP-14

+ 36 Gy (Bulk, E)

Random

2x2

Factorial

Design

8

x CHOP-14

+ 36 Gy (Bulk, E)

8

x CHOP-14

+ 36 Gy (Bulk, E)

+ 8 x Rituximab

6

x CHOP-14

+ 36 Gy (Bulk, E)

+ 8 x Rituximab

Pfreundschuh, Lancet Oncol,

2008

RICOVER-60

CD20

+

DLBCL

Stage I-IV

61 - 80 years

RICOVER-60-no-RT

6 x CHOP-14

+ 36 Gy (Bulk, E)

+ 8 x Rituximab

RICOVER-60-no-RT:

-3rd Amendment

-Recruitment 08/2005 – 10/2007

-Number of Patients 166

-Median Observation 39 Months

Held, JCO 2014l