1487 / 1498
6
x CHOP-14
+ 36 Gy (Bulk, E)
Random
2x2
Factorial
Design
8
x CHOP-14
+ 36 Gy (Bulk, E)
8
x CHOP-14
+ 36 Gy (Bulk, E)
+ 8 x Rituximab
6
x CHOP-14
+ 36 Gy (Bulk, E)
+ 8 x Rituximab
Pfreundschuh, Lancet Oncol,
2008
RICOVER-60
CD20
+
DLBCL
Stage I-IV
61 - 80 years
RICOVER-60-no-RT
6 x CHOP-14
+ 36 Gy (Bulk, E)
+ 8 x Rituximab
RICOVER-60-no-RT:
-3rd Amendment
-Recruitment 08/2005 – 10/2007
-Number of Patients 166
-Median Observation 39 Months
Held, JCO 2014l