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6 x CHOP-

21

+ RT (Bulk, E)

Random

2x2

Factorial

Design

6 x CHOP-

21

+ no RT

6 x CHOP-

14

+ no RT

6 x CHOP-

14

+ RT (Bulk, E)

UNFOLDER

CD20

+

DLBCL

IPI=1

&/or

Bulk