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General principles of management
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Early stage:
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Low-grade: curative RT
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High-grade: CMT if RT feasible. Full course chemo alone if not.
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Tolerability of chemo
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Response to chemo
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Morbidity of RT
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Suitability for future salvage
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Advanced stage:
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Low-grade: systemic Rx ± RT for local control
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High-grade: systemic Rx ± consolidation RT to sites of EN disease