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RT in PCNSL – Take home

WBRT an effective tool in many stages of treatment

Best use of RET is as low dose (24 Gy) after CR to MTX

Full dose RT after MTX is toxic in age >60 years

Chemotherapy alone in “full” MTX doses or with ASCT

transplant is also toxic, but is often considered

Patients respond (yet, temporarily) to salvage with RT

alone or with chemotherapy