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Risk of breast cancer after RT for HL, by

duration of ovarian function after RT

0

1

2

3

4

5

6

< 10 yrs

10-20 yrs

>=20 yrs

Reference

0.3 [0.2-0.6]

5.3 [2.9-9.9]

years of intact ovarian function after RT

Hazard ratio

Ovarian hormones crucial in radiation-induced breast carcinogenesis

De Bruin et al, JCO 2009