232 / 1498
Breast cancer following HL
a Dutch case-control study
van Leeuwen JNCI 2003: 95;971
Radiation dose in Gy
(median)
Cases
Controls
OR†
95%CI
<4 (3.6)
9
47
1.0*
Ref
4-24 (15.5)
10
39
1.11
0.32-3.85
24-38.5 (30.2)
14
44
4.20
0.99-17.8
≥
38.5 (40.7)
15
45
5.16
1.27-21.0
Overall treatment
Cases
Controls
OR†
95%CI
RT only
30
68
1.0
Ref
RT+CT
18
104
0.45
0.22-0.91
* P trend <0.001; † adjusted for RT dose ovary and CT
•
Highest risks in youngest patients
• Induction period: 10-15 years