1243 / 1708
Principle of Benefit
From first principles, it would follow that
the largest
benefit
for protons will be
in the youngest patients
(at
risk for late RT effects for the longest period of time)
with
potentially curative
(either localised or oligometastatic)
tumours, requiring RT to
large target volumes
(where a larger normal tissue volume would be spared
exit dose) or to a large proportion of a critical organ
(i.e. eye, liver, and spinal cord) to
high RT doses
.
T. Delaney & R. Haas, 2016