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PT and SMN
Lower integral dose with protons could also reduce the
risk of RT associated secondary malignancies.
•
Chung et al. 2013
:
compared 558 proton patients with 558 matched patients
(mainly adults), med. FU 6.7. and 6.0 years.
On multi-
variable analysis, PRT was associated with a
decreased risk of SMN
[adjusted hazard ratio,
0.52,
p
= 0.009]
•
Sethi et al. 2014:
SMN among patients treated PT or XRT for RB, med. FU
6.9
for PT/ 13.1 years for XRT, the 10-year cumulative
incidence of
RT-induced SMN was significantly less
among the proton cohort
(0 vs. 14%, p = 0.015)