290 / 1708
SIOP 2
•
1984-1989
•
446 patients registered, 364 randomised
•
Randomised study of pre-RT chemotherapy:
➢
Procarbazine, VCR, MTX
•
High-risk cases based on SIOP 1 parameters
routinely given post-RT VCR/CCNU chemo
•
No benefit for pre-RT chemotherapy
•
Radiotherapy dose randomisation (35 Gy vs 25
Gy) for low-risk cases
➢
Bailey CC et al, Med Pediatr Oncol 1995; 25: 166-178