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HIT/SIOP Study for

Non-Metastatic (M0) Medulloblastoma (PNET-4)

2000 - 2006

Can HFRT improve therapeutic ratio for RT?:

Can event-free survival be improved without

an increase in neuropsychological long-term

effects?

Standardised assessment of long-term effects -

Health Utilities Index (HUI), endocrine

assessment

Prospective evaluation of biological markers