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Infant (age < 3) Medulloblastoma
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Late effects problematic
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Higher risk of M+ disease
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Historically poor prognosis
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Relatively lower proportion have received a complete
resection compared with older children
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Generally RT avoidance strategies have resulted in adverse
disease control outcomes
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GPOH study of chemotherapy alone successful in infants
with desmoplastic histology – includes intraventricular
methotrexate
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Intensive chemotherapy – long-term outcomes not clear
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Balance between tumour control and toxicity still unclear
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Ongoing clinical trials