299 / 1708
HIT 91, Patients aged 6-18
Kortmann et al, 2000, IJROBP 46, 269-279
•
1991 - 1997
•
158 patients enrolled, 137 randomised
•
Sandwich chemotherapy (ifosfamide,
etoposide, MTX, cisplatin, cytarabine) vs post-
RT CVP
•
Overall 3 year RFS 70%
•
M0: 72%, M1: 65%, M2/3: 30%
•
M0-1 – Pre-RT chemotherapy: 65%
•
Immediate RT: 78% (p = <0.03)