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Reduced Health Status Following Pre-RT
Chemotherapy and Craniospinal Irradiation
•
PNET-3 Study (1992-2000) – Randomised Study of Pre-RT
chemotherapy vs RT alone
•
73% of 147 eligible patients aged 6.6 to 24.3 years were
assessed at a mean of 7.2 years after diagnosis
•
Health status was significantly poorer in the group treated
in the CSI plus CT arm of the trial
•
Also trends to poorer outcomes for behaviour and quality of
life scores
•
The CSI plus CT group were also significantly more
restricted physically and needed more therapeutic and
educational support
➢
Bull KS, Spoudeas HA, Yadegarfar G, Kennedy CR
➢
J Clin Oncol
2007; 25: 4239-4245