344 / 1708
Nr. 11
PNET5 – SHH-TP53
Key inclusion criteria:
-
SHH MB with
TP53
muta$on
-
TP53
germline evalua$on mandatory
-
All histology subtypes
-
M0 and M+
-
>3-5 years with no upper age limit
MRI
MRI
MRI
MRI
MRI
MRI
LP
OP Chemotherapy Radiotherapy
Vinblas$n
≤4w 16w ≤4w 6w
4*-
6w
24w
* In pa$ents with local radiotherapy only
SKK like SKK like
+VCR
“SKK-like” chemotherapy (with i.ventr. MTX):
w1: Doxorubicin (or Carbopla$n)/VCR
w3, w5: HD-MTX/VCR
w7: Carbopla$n/VCR
Radiotherapy
(with weekly VCR 1,5mg/m
2
)
:
Germline
TP53mut
M0:
Focal RT
Safety margin 23.4 Gy, tumor 54.0 Gy,
Germline
TP53mut
M+:CSI 23.4 Gy
,
tumor 54.0 Gy
Soma$c
TP53mut
: CSI 36.0 Gy, tumor 54.0 Gy