345 / 1708
Nr. 12
PNET5 – WNT-HR
MRI
MRI
MRI
MRI
MRI
LP
6w 3w
OP Radiotherapy
Chemotherapy
≤4 w 6w 6w
27
-36w
(≥ 16 years)
A B A B A B
( A B)
Key inclusion criteria:
-
WNT posi$ve with HR-features:
-
age ≥ 16 years and /or
-
M+ and/or
-
R+
-
CMB, DMB or LCAMB
-
MYC/MYCN nega$ve or posi$ve
-
WNT without
CTNNB1
muta$on (if not
germline APC-muta$on, rare)
Radiotherapy:
<16 years and ≥ 16 years without metastasis:
CSI
23.4 Gy,
primary tumor 54.0 Gy
≥ 16 years and metastasis:
CSI
36.0 Gy
, primary tumor 54.0 Gy